Genetic modification of acetogens and optimization of fermentation process in C1-gas bioconversion.

Author: Sai WAN ¹ ; Haoming WANG ¹ ; Xiaoqing MA ¹ ; Yang TAN ¹ ; Licheng LIU ¹ ; Fuli LI ¹
Author Information

1. Qingdao C1 Refinery Engineering Research Center, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, Shandong, China.
Publication Type:Journal Article
Keywords: acetogens; fermentation process; genetic engineering; microbial fermentation; single carbon gas
MeSH: Fermentation; Gases/metabolism*; Carbon Dioxide/metabolism*; Metabolic Engineering; Carbon/metabolism*
From: Chinese Journal of Biotechnology 2023;39(6):2410-2429
CountryChina
Language:Chinese
Abstract: The current linear economy model relies on fossil energy and increases CO₂ emissions, which contributes to global warming and environmental pollution. Therefore, there is an urgent need to develop and deploy technologies for carbon capture and utilization to establish a circular economy. The use of acetogens for C1-gas (CO and CO₂) conversion is a promising technology due to high metabolic flexibility, product selectivity, and diversity of the products including chemicals and fuels. This review focuses on the physiological and metabolic mechanisms, genetic and metabolic engineering modifications, fermentation process optimization, and carbon atom economy in the process of C1-gas conversion by acetogens, with the aim to facilitate the industrial scale-up and carbon negative production through acetogen gas fermentation.