Biosynthesis of natural products by non-conventional yeasts.

Zhilan Qian; Lili Song; Qi Liu; Xiulong Gong; Yijia Kang; Ziyu HE; Haoyu Long; Menghao Cai

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Biosynthesis of natural products by non-conventional yeasts.

Author: Zhilan QIAN ¹ ; Lili SONG ¹ ; Qi LIU ¹ ; Xiulong GONG ¹ ; Yijia KANG ¹ ; Ziyu HE ¹ ; Haoyu LONG ¹ ; Menghao CAI ¹
Author Information

1. School of Biotechnology, East China University of Science and Technology, Shanghai 200237, China.
Publication Type:Journal Article
Keywords: cell factories; metabolic engineering; natural products; non-conventional yeasts
MeSH: Yeasts/genetics*; Yarrowia/metabolism*; Gene Editing; Metabolic Engineering
From: Chinese Journal of Biotechnology 2023;39(6):2284-2312
CountryChina
Language:Chinese
Abstract: Non-conventional yeasts such as Yarrowia lipolytica, Pichia pastoris, Kluyveromyces marxianus, Rhodosporidium toruloides and Hansenula polymorpha have proven to be efficient cell factories in producing a variety of natural products due to their wide substrate utilization spectrum, strong tolerance to environmental stresses and other merits. With the development of synthetic biology and gene editing technology, metabolic engineering tools and strategies for non-conventional yeasts are expanding. This review introduces the physiological characteristics, tool development and current application of several representative non-conventional yeasts, and summarizes the metabolic engineering strategies commonly used in the improvement of natural products biosynthesis. We also discuss the strengths and weaknesses of non-conventional yeasts as natural products cell factories at current stage, and prospects future research and development trends.