Advances on the microbial synthesis of plant-derived diterpenoids.
- Author:
Yatian CHENG
1
;
Hao TANG
1
;
Lili SUN
1
;
Yating HU
2
;
Ying MA
1
;
Juan GUO
1
;
Luqi HUANG
1
Author Information
- Publication Type:Journal Article
- Keywords: metabolic engineering; microbial synthesis; plant-derived diterpenoids; synthetic biology
- MeSH: Diterpenes/metabolism*; Biotechnology; Metabolic Engineering; Biosynthetic Pathways/genetics*; Plants/genetics*; Synthetic Biology
- From: Chinese Journal of Biotechnology 2023;39(6):2265-2283
- CountryChina
- Language:Chinese
- Abstract: Natural plant-derived diterpenoids are a class of compounds with diverse structures and functions. These compounds are widely used in pharmaceuticals, cosmetics and food additives industries because of their pharmacological properties such as anticancer, anti-inflammatory and antibacterial activities. In recent years, with the gradual discovery of functional genes in the biosynthetic pathway of plant-derived diterpenoids and the development of synthetic biotechnology, great efforts have been made to construct a variety of diterpenoid microbial cell factories through metabolic engineering and synthetic biology, resulting in gram-level production of many compounds. This article summarizes the construction of plant-derived diterpenoid microbial cell factories through synthetic biotechnology, followed by introducing the metabolic engineering strategies applied to improve plant-derived diterpenoids production, with the aim to provide a reference for the construction of high-yield plant-derived diterpenoid microbial cell factories and the industrial production of diterpenoids.
