Microbial production of S-adenosyl-l-methionine: a review.

Meijing LI; Zheyan MI; Jinhao Wang; Zhongce HU; Haibin Qin; Yuanshan Wang; Yuguo Zheng

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Microbial production of S-adenosyl-l-methionine: a review.

Author: Meijing LI ¹ ; Zheyan MI ¹ ; Jinhao WANG ¹ ; Zhongce HU ¹ ; Haibin QIN ¹ ; Yuanshan WANG ¹ ; Yuguo ZHENG ¹
Author Information

1. College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
Publication Type:Journal Article
Keywords: S-adenosyl-l-methionine; conventional breeding; metabolic engineering; physiological function
MeSH: S-Adenosylmethionine/metabolism*; Plant Breeding; Fermentation; Metabolic Engineering
From: Chinese Journal of Biotechnology 2023;39(6):2248-2264
CountryChina
Language:Chinese
Abstract: S-adenosyl-l-methionine (SAM) is ubiquitous in living organisms and plays important roles in transmethylation, transsulfuration and transamination in organisms. Due to its important physiological functions, production of SAM has attracted increasing attentions. Currently, researches on SAM production mainly focus on microbial fermentation, which is more cost-effective than that of the chemical synthesis and the enzyme catalysis, thus easier to achieve commercial production. With the rapid growth in SAM demand, interests in improving SAM production by developing SAM hyper-producing microorganisms aroused. The main strategies for improving SAM productivity of microorganisms include conventional breeding and metabolic engineering. This review summarizes the recent research progress in improving microbial SAM productivity to facilitate further improving SAM productivity. The bottlenecks in SAM biosynthesis and the solutions were also addressed.