Expression of the RERG Gene is Gender-Dependent in Hepatocellular Carcinoma and Regulated by Histone Deacetyltransferases.
10.3346/jkms.2006.21.5.891
- Author:
Ai Guo WANG
1
;
Wan FANG
;
Ying Hao HAN
;
Sang Mi CHO
;
Jong Young CHOI
;
Kee Ho LEE
;
Wook Hwan KIM
;
Jin Man KIM
;
Moon Gi PARK
;
Dae Yeul YU
;
Nam Soon KIM
;
Dong Seok LEE
Author Information
1. Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea. dslee@kangwon.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Ras-Related Estrogen-Regulated and Growth-Inhibitory Gene (RERG);
Carcinoma, Hepatocel-lular;
Sex;
Histone Acetyltransferases
- MeSH:
Signal Transduction;
Sex Factors;
Mice, Transgenic;
Mice, Inbred C57BL;
Mice;
Male;
Liver Neoplasms/*genetics;
Humans;
Histone Deacetylases/*physiology;
Hepatocytes/metabolism;
Growth Inhibitors/*genetics;
*Genes, ras;
*Gene Expression Regulation, Neoplastic;
Female;
Estrogens/*pharmacology;
Estrogen Receptor alpha/analysis;
Cell Proliferation;
Animals
- From:Journal of Korean Medical Science
2006;21(5):891-896
- CountryRepublic of Korea
- Language:English
-
Abstract:
Ras-related, estrogen-regulated, and growth-inhibitory gene (RERG) is a novel gene that was first reported in breast cancer. However, the functions of RERG are largely unknown in other tumor types. In this study, RERG expression was analyzed in hepatocellular carcinomas of human patients using reverse transcriptase PCR analysis. In addition, the possible regulation of RERG expression by histone deacetyltransferases (HDACs) was studied in several cell lines. Interestingly, the expression of RERG gene was increased in hepatocellular carcinoma (HCC) of male patients (57.9%) but decreased in HCC of females (87.5%) comparison with paired peri-tumoral tissues. Moreover, RERG gene expression was increased in murine hepatoma Hepa1-6 cells, human breast tumor MDA-MB-231 cells, and mouse normal fibroblast NIH3T3 cells after treated by HDAC inhibitor, trichostatin A. Our results suggest that RERG may function in a gender-dependent manner in hepatic tumorigenesis and that the expression of this gene may be regulated by an HDAC-related signaling pathway.
