Advances in poly(ethylene terephthalate) hydrolases.
- Author:
Zhiyi ZHAO
1
;
Guoqiang ZHANG
1
;
Kun LIU
1
;
Shengying LI
1
Author Information
- Publication Type:Journal Article
- Keywords: PET hydrolase; catalytic mechanism; enzyme engineering; plastic degradation; poly(ethylene terephthalate)
- MeSH: Humans; Hydrolases/metabolism*; Polyethylene Terephthalates/metabolism*; Plastics/metabolism*; Ethylenes
- From: Chinese Journal of Biotechnology 2023;39(5):1998-2014
- CountryChina
- Language:Chinese
- Abstract: Plastics have brought invaluable convenience to human life since it was firstly synthesized in the last century. However, the stable polymer structure of plastics led to the continuous accumulation of plastic wastes, which poses serious threats to the ecological environment and human health. Poly(ethylene terephthalate) (PET) is the most widely produced polyester plastics. Recent researches on PET hydrolases have shown great potential of enzymatic degradation and recycling of plastics. Meanwhile, the biodegradation pathway of PET has become a reference model for the biodegradation of other plastics. This review summarizes the sources of PET hydrolases and their degradation capacity, degradation mechanism of PET by the most representative PET hydrolase-IsPETase, and recently reported highly efficient degrading enzymes through enzyme engineering. The advances of PET hydrolases may facilitate the research on the degradation mechanism of PET and further exploration and engineering of efficient PET degradation enzymes.
