Advances of the regulatory mechanism of cyclin, cyclin- dependent kinases and related kinase inhibitors in cell cycle progression.
- Author:
Jianfeng PAN
1
;
Fangzheng SHANG
1
;
Rong MA
1
;
Youjun RONG
1
;
Yanjun ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: cancer; cell cycle; cyclin; cyclin dependent kinase (CDK); cyclin dependent kinase inhibitor (CKI)
- MeSH: Cyclin-Dependent Kinases/metabolism*; Cyclins/metabolism*; Protein Serine-Threonine Kinases; Cell Cycle Proteins/metabolism*; Cell Cycle/physiology*; Cyclin-Dependent Kinase 2
- From: Chinese Journal of Biotechnology 2023;39(4):1525-1547
- CountryChina
- Language:Chinese
- Abstract: Cell cycle plays a crucial role in cell development. Cell cycle progression is mainly regulated by cyclin dependent kinase (CDK), cyclin and endogenous CDK inhibitor (CKI). Among these, CDK is the main cell cycle regulator, binding to cyclin to form the cyclin-CDK complex, which phosphorylates hundreds of substrates and regulates interphase and mitotic progression. Abnormal activity of various cell cycle proteins can cause uncontrolled proliferation of cancer cells, which leads to cancer development. Therefore, understanding the changes in CDK activity, cyclin-CDK assembly and the role of CDK inhibitors will help to understand the underlying regulatory processes in cell cycle progression, as well as provide a basis for the treatment of cancer and disease and the development of CDK inhibitor-based therapeutic agents. This review focuses on the key events of CDK activation or inactivation, and summarizes the regulatory processes of cyclin-CDK at specific times and locations, as well as the progress of research on relevant CDK inhibitor therapeutics in cancer and disease. The review concludes with a brief description of the current challenges of the cell cycle process, with the aim to provide scientific references and new ideas for further research on cell cycle process.
