The action mechanism of glioblastoma cell-derived exosome: a review.

Na LI; Li Luo; Yating Yang; Zhaomei Liu; Xiaoyan Qiu; Mingyu Wang; Wei Wang; Xiong Xiao

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The action mechanism of glioblastoma cell-derived exosome: a review.

Author: Na LI ¹ ; Li LUO ¹ ; Yating YANG ¹ ; Zhaomei LIU ¹ ; Xiaoyan QIU ² ; Mingyu WANG ³ ; Wei WANG ¹ ; Xiong XIAO ¹
Author Information

1. College of Veterinary Medicine, Southwest University, Chongqing 400715, China.
2. College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
3. Institute of Laboratory Animal Science, Chongqing Academy of Chinese Materia Medica, Chongqing 400065, China.
Publication Type:Journal Article
Keywords: angiogenesis; cell proliferation; drug resistance; exosome; glioblastoma; immune evasion
MeSH: Humans; Glioblastoma/genetics*; Exosomes/metabolism*; MicroRNAs/metabolism*; Prognosis; Cell Proliferation; Brain Neoplasms/genetics*; Cell Line, Tumor
From: Chinese Journal of Biotechnology 2023;39(4):1477-1501
CountryChina
Language:Chinese
Abstract: Patients with glioblastoma (GBM) generally have a bad prognosis and short overall survival after being treated with surgery, chemotherapy or radiotherapy due to the histological heterogeneity, strong invasive ability and rapid postoperative recurrence of GBM. The components of GBM cell-derived exosome (GBM-exo) can regulate the proliferation and migration of GBM cell via cytokines, miRNAs, DNA molecules and proteins, promote the angiogenesis via angiogenic proteins and non-coding RNAs, mediate tumor immune evasion by targeting immune checkpoints with regulatory factors, proteins and drugs, and reduce drug resistance of GBM cells through non-coding RNAs. GBM-exo is expected to be an important target for the personalized treatment of GBM and a marker for diagnosis and prognosis of this kind of disease. This review summarizes the preparation methods, biological characteristics, functions and molecular mechanisms of GBM-exo on cell proliferation, angiogenesis, immune evasion and drug resistance of GBM to facilitate developing new strategies for the diagnosis and treatment of GBM.