Advances in genomics of multi-drug resistant <i>Stenotrophomonas</i>.

Yuhang Tang; Shiqi Fang; Linlin Xie; Chao Sun; Shanshan LI; Aiping Zhou; Guangxiang Cao; Jun LI

Return

Advances in genomics of multi-drug resistant Stenotrophomonas.

Author: Yuhang TANG ¹ ; Shiqi FANG ² ; Linlin XIE ¹ ; Chao SUN ² ; Shanshan LI ² ; Aiping ZHOU ³ ; Guangxiang CAO ⁴ ; Jun LI ²
Author Information

1. College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, Zhejiang, China.
2. College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, Jiangxi, China.
3. Shanghai East Hospital, Shanghai 200123, China.
4. Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji՚nan 250117, Shandong, China.
Publication Type:Journal Article
Keywords: Stenotrophomonas; genomics; multi-drug resistance; transferability risk
MeSH: Stenotrophomonas/genetics*; Drug Resistance, Bacterial/genetics*; Anti-Bacterial Agents/pharmacology*; Gram-Negative Bacteria; Genomics; Microbial Sensitivity Tests
From: Chinese Journal of Biotechnology 2023;39(4):1314-1331
CountryChina
Language:Chinese
Abstract: Stenotrophomonas species are non-fermentative Gram-negative bacteria that are widely distributed in environment and are highly resistant to numerous antibiotics. Thus, Stenotrophomonas serves as a reservoir of genes encoding antimicrobial resistance (AMR). The detection rate of Stenotrophomonas is rapidly increasing alongside their strengthening intrinsic ability to tolerate a variety of clinical antibiotics. This review illustrated the current genomics advances of antibiotic resistant Stenotrophomonas, highlighting the importance of precise identification and sequence editing. In addition, AMR diversity and transferability have been assessed by the developed bioinformatics tools. However, the working models of AMR in Stenotrophomonas are cryptic and urgently required to be determined. Comparative genomics is envisioned to facilitate the prevention and control of AMR, as well as to gain insights into bacterial adaptability and drug development.