Study on the mechanism of curcumin in the treatment of periodontitis through network pharmacology and mole-cular docking.
10.7518/hxkq.2023.2022370
- Author:
Jingmei YANG
1
;
Ziliang ZHOU
2
;
Yafei WU
1
;
Min NIE
3
Author Information
1. State Key Laboratory of Oral Disease & National Clinical Research Center for Oral Disease & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
2. Dept. of Oral Emergency and General Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou 510140, China.
3. Dept. of Periodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou 510140, China.
- Publication Type:Journal Article
- Keywords:
curcumin;
mechanism;
molecular docking analysis;
network pharmacology;
periodontitis
- MeSH:
Humans;
Network Pharmacology;
Curcumin/therapeutic use*;
Molecular Docking Simulation;
Periodontitis/drug therapy*;
Drugs, Chinese Herbal;
Medicine, Chinese Traditional
- From:
West China Journal of Stomatology
2023;41(2):157-164
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:This study aims to explore the therapeutic targets of curcumin in periodontitis through network pharmacology and molecular docking technology.
METHODS:Targets of curcumin and periodontitis were predicted by different databases, and the protein-protein interaction (PPI) network constructed by String revealed the interaction between curcumin and periodontitis. The key target genes were screened for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Molecular docking was performed to analyze the binding potential of curcumin to periodontitis.
RESULTS:A total of 672 periodontitis-related disease targets and 107 curcumin-acting targets were obtained from the databases, and 20 key targets were screened. The GO and KEGG analyses of the 20 targets showed that curcumin might play a therapeutic role through the hypoxia-inducible factor (HIF)-1 and parathyroid hormone (PTH) signaling pathways. Molecular docking analysis showed that curcumin had good binding potential with multiple targets.
CONCLUSIONS:The potential key targets and molecular mechanisms of curcumin in treating periodontitis provide a theoretical basis for new drug development and clinical applications.
