Diagnostic Efficacy of 18F-FDG PET/CT in Detecting Bone Marrow Infiltration in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma.
- Author:
Bo GUO
1
;
Ran QIN
1
;
Zhen Yang GU
2
;
Yan Fen LI
2
;
Lei GAO
3
;
Wen Rong HUANG
2
Author Information
- Publication Type:Journal Article
- Keywords: Bone marrow biopsy; Bone marrow infiltration; Diagnostic efficacy; Diffuse large B-cell lymphoma; Positron emission computed tomography (PET/CT)
- MeSH: Humans; Positron Emission Tomography Computed Tomography/methods*; Fluorodeoxyglucose F18; Bone Marrow/pathology*; Retrospective Studies; Positron-Emission Tomography/methods*; Lymphoma, Large B-Cell, Diffuse/pathology*
- From: Biomedical and Environmental Sciences 2023;36(6):510-516
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:Diffuse large B-cell lymphoma (DLBCL) is often associated with bone marrow infiltration, and 2-deoxy-2-(18F) fluorodeoxyglucose positron emission tomography/computed tomography ( 18F-FDG PET/CT) has potential diagnostic significance for bone marrow infiltration in DLBCL.
METHODS:A total of 102 patients diagnosed with DLBCL between September 2019 and August 2022 were included. Bone marrow biopsy and 18F-FDG PET/CT examinations were performed at the time of initial diagnosis. Kappa tests were used to evaluate the agreement of 18F-FDG PET/CT with the gold standard, and the imaging features of DLBCL bone marrow infiltration on PET/CT were described.
RESULTS:The total detection rate of bone marrow infiltration was not significantly different between PET/CT and primary bone marrow biopsy ( P = 0.302) or between the two bone marrow biopsies ( P = 0.826). The sensitivity, specificity, and Youden index of PET/CT for the diagnosis of DLBCL bone marrow infiltration were 0.923 (95% CI, 0.759-0.979), 0.934 (95% CI, 0.855-0.972), and 0.857, respectively.
CONCLUSION:18F-FDG PET/CT has a comparable efficiency in the diagnosis of DLBCL bone marrow infiltration. PET/CT-guided bone marrow biopsy can reduce the misdiagnosis of DLBCL bone marrow infiltration.
