Obesity is positively Associated with Depression in Older Adults: Role of Systemic Inflammation.

Ye Xin Guo; An Qi Wang; Xin Gao; Jun NA; Wei Zhe; Yi Zeng; Jing Rui Zhang; Yuan Jing Jiang; Fei Yan; Mukaram Yunus; Hui Wang; Zhao Xue Yin

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Obesity is positively Associated with Depression in Older Adults: Role of Systemic Inflammation.

Author: Ye Xin GUO ¹ ; An Qi WANG ¹ ; Xin GAO ¹ ; Jun NA ² ; Wei ZHE ³ ; Yi ZENG ^{4
,

5} ; Jing Rui ZHANG ⁶ ; Yuan Jing JIANG ⁷ ; Fei YAN ⁶ ; Mukaram YUNUS ⁷ ; Hui WANG ⁸ ; Zhao Xue YIN ¹
Author Information

1. Division of Non-communicable Diseases and Elderly Health Management, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
2. Liaoning Provincial Center for Diseases Control and Prevention, Shenyang 110000, Liaoning, China.
3. Xinjiang Uygur Autonomous Region Centre for Disease Control and Prevention, Urumqi 830002, Xinjiang, China.
4. Center for the Study of Aging and Human Development and the Geriatric Division of School of Medicine, Duke University, Durham 27701, NC, USA
5. Center for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing 100871, China.
6. Yuanbao Center for Diseases Control and Prevention, Dandong 118000, Liaoning, China.
7. Korla Center for Diseases Control and Prevention, Korla 841000, Xinjiang, China.
8. Liudaokou Community Health Service Centre, Dandong 118000, Liaoning, China.
Publication Type:Journal Article
Keywords: Body mass index; Depression; Inflammatory reaction; Obesity; Older adults
MeSH: Humans; Male; Aged; Depression/etiology*; C-Reactive Protein/metabolism*; Obesity, Abdominal/epidemiology*; Longitudinal Studies; Inflammation/epidemiology*; Obesity/complications*
From: Biomedical and Environmental Sciences 2023;36(6):481-489
CountryChina
Language:English
Abstract: OBJECTIVE:We aimed to explore the association between obesity and depression and the role of systemic inflammation in older adults.
METHODS:Adults ≥ 65 years old ( n = 1,973) were interviewed at baseline in 2018 and 1,459 were followed up in 2021. General and abdominal obesity were assessed, and serum C-reactive protein (CRP) levels were measured at baseline. Depression status was assessed at baseline and at follow-up. Logistic regression was used to analyze the relationship between obesity and the incidence of depression and worsening of depressive symptoms, as well as the relationship between obesity and CRP levels. The associations of CRP levels with the geriatric depression scale, as well as with its three dimensions, were investigated using multiple linear regressions.
RESULTS:General obesity was associated with worsening depression symptoms and incident depression, with an odds ratio ( OR) [95% confidence interval ( CI)] of 1.53 (1.13-2.12) and 1.80 (1.23-2.63), especially among old male subjects, with OR (95% CI) of 2.12 (1.25-3.58) and 2.24 (1.22-4.11), respectively; however, no significant relationship was observed between abdominal obesity and depression. In addition, general obesity was associated with high levels of CRP, with OR (95% CI) of 2.58 (1.75-3.81), especially in subjects free of depression at baseline, with OR (95% CI) of 3.15 (1.97-5.04), and CRP levels were positively correlated with a score of specific dimension (life satisfaction) of depression, P < 0.05.
CONCLUSION:General obesity, rather than abdominal obesity, was associated with worsening depressive symptoms and incident depression, which can be partly explained by the systemic inflammatory response, and the impact of obesity on depression should be taken more seriously in the older male population.