HIV-1 Transmission among Injecting Drug Users is Principally Derived from Local Circulating Strains in Guangxi, China.

Ping Cen; Hua Yue Liang; Yuan Yang; Fei Zhang; Shi Xiong Yang; Ju Cong MO; Yi Feng; Jie Gang Huang; Chuan Yi Ning; Chun Yuan Huang; Yao Yang; Na Liang; Bing Yu Liang; Li YE; Hao Liang

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HIV-1 Transmission among Injecting Drug Users is Principally Derived from Local Circulating Strains in Guangxi, China.

Author: Ping CEN ^{1
,

2
,

3} ; Hua Yue LIANG ⁴ ; Yuan YANG ⁵ ; Fei ZHANG ⁴ ; Shi Xiong YANG ³ ; Ju Cong MO ³ ; Yi FENG ⁶ ; Jie Gang HUANG ⁴ ; Chuan Yi NING ⁴ ; Chun Yuan HUANG ⁴ ; Yao YANG ⁴ ; Na LIANG ⁴ ; Bing Yu LIANG ^{1
,

5} ; Li YE ^{1
,

5} ; Hao LIANG ^{1
,

5}
Author Information

1. Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China
2. Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Life Science Institute, Guangxi Medical University, Nanning 530021, Guangxi, China
3. Nanning Center for Disease Control and Prevention, Nanning 530023, Guangxi, China.
4. Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China.
5. Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Life Science Institute, Guangxi Medical University, Nanning 530021, Guangxi, China.
6. State Key Laboratory of Infectious Disease Prevention and Control (SKLID), Chinese Center for Disease Control and Prevention (China CDC), Collaborative Center for Diagnosis and Treatment of Infectious Disease, Beijing 102206, China.
Publication Type:Journal Article
Keywords: HIV-1; Injection drug use; Phylogenetics; Strain source; Transmission
MeSH: Humans; HIV-1/genetics*; HIV Infections; Drug Users; Phylogeny; Bayes Theorem; China/epidemiology*; Genotype
From: Biomedical and Environmental Sciences 2023;36(5):418-430
CountryChina
Language:English
Abstract: OBJECTIVE:The mode of human immunodeficiency virus (HIV) transmission via injection drug use (IDU) still exists, and the recent shift in IDU-related transmission of HIV infection is largely unknown. The purpose of this study was to analyze the spatiotemporal sources and dynamics of HIV-1 transmission through IDU in Guangxi.
METHODS:We performed a molecular epidemiological investigation of infections across Guangxi from 2009 to 2019. Phylogenetic and Bayesian time-geographic analyses of HIV-1 sequences were performed to confirm the characteristics of transmission between IDUs in combination with epidemiological data.
RESULTS:Among the 535 subjects, CRF08_BC (57.4%), CRF01_AE (28.4%), and CRF07_BC (10.7%) were the top 3 HIV strains; 72.6% of infections were linked to other provinces in the transmission network; 93.6% of sequence-transmitted strains were locally endemic, with the rest coming from other provinces, predominantly Guangdong and Yunnan; 92.1% of the HIV transmission among people who inject drugs tended to be transmitted between HIV-positive IDUs.
CONCLUSION:HIV recombinants were high diversity, and circulating local strains were the transmission sources among IDUs in Guangxi. However, there were still cases of IDUs linked to other provinces. Coverage of traditional prevention strategies should be expanded, and inter-provincial collaboration between Guangxi, Yunnan, and Guangdong provinces should be strengthened.