Exercise regulates bone metabolism via microRNAs.
- Author:
Yu YUAN
1
;
Lin-Zhen RAO
1
;
Shi-Hua ZHANG
1
;
Yang XU
1
;
Ting-Ting LI
2
;
Jun ZOU
2
;
Xi-Quan WENG
3
Author Information
1. School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China.
2. School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.
3. School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China. wengxq@gzsport.edu.cn.
- Publication Type:Journal Article
- MeSH:
Humans;
MicroRNAs/metabolism*;
Osteogenesis/genetics*;
Cell Differentiation;
Osteoblasts;
Bone Resorption/metabolism*
- From:
Acta Physiologica Sinica
2023;75(3):429-438
- CountryChina
- Language:Chinese
-
Abstract:
It has been well documented that exercise can improve bone metabolism, promote bone growth and development, and alleviate bone loss. MicroRNAs (miRNAs) are widely involved in the proliferation and differentiation of bone marrow mesenchymal stem cells, osteoblasts, osteoclasts and other bone tissue cells, and regulation of balance between bone formation and bone resorption by targeting osteogenic factors or bone resorption factors. Thus miRNAs play an important role in the regulation of bone metabolism. Recently, regulation of miRNAs are shown to be one of the ways by which exercise or mechanical stress promotes the positive balance of bone metabolism. Exercise induces changes of miRNAs expression in bone tissue and regulates the expression of related osteogenic factors or bone resorption factors, to further strengthen the osteogenic effect of exercise. This review summarizes relevant studies on the mechanism whereby exercise regulates bone metabolism via miRNAs, providing a theoretical basis for osteoporosis prevention and treatment with exercise.
