IL-27: a novel cytokine mediating immune related diseases.
- Author:
Na ZHANG
1
;
Yang YANG
1
;
Qiu-Yan LIANG
1
;
Xiao-Rui DIAO
1
;
Xue-Jie YI
1
;
Bo CHANG
2
Author Information
1. School of Sports and Human Sciences, Shenyang Sport University, Shenyang 110115, China.
2. School of Sports and Human Sciences, Shenyang Sport University, Shenyang 110115, China. changbo8387@163.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Cytokines;
Interleukin-27;
Autoimmune Diseases;
Arthritis, Rheumatoid;
Neoplasms
- From:
Acta Physiologica Sinica
2023;75(2):303-315
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin 27 (IL-27) is a pleiotropic cytokine that is involved in the regulation of the body's innate and adaptive immunity. Previous studies have shown that IL-27 mediates a variety of inflammatory responses in vivo. With the development of animal models and technical tools, several studies have shown that it is also closely associated with autoimmune diseases and other immune related diseases, and is considered as an important candidate for the treatment of viral disease, autoimmune diseases, tumors and obesity. Therefore, this paper reviews recent progress on the role of IL-27 in acquired immunodeficiency syndrome (AIDS), rheumatoid arthritis, tumors and obesity, with the aim of providing new ideas for the treatment of immune related diseases.
