Progress in application of adult endogenous neurogenesis in brain injury repair.
- Author:
Tian-Yu BAI
1
;
Jiao MU
1
;
Peng HAO
2
;
Hong-Mei DUAN
2
;
Fei HAO
1
;
Wen ZHAO
2
;
Yu-Dan GAO
2
;
Zi-Jue WANG
2
;
Zhao-Yang YANG
2
;
Xiao-Guang LI
1
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Animals; Humans; Brain/physiopathology*; Hippocampus/physiopathology*; Mammals/physiology*; Neurogenesis/physiology*; Brain Hemorrhage, Traumatic/therapy*; Ischemic Stroke/therapy*; Recovery of Function; Spinal Cord/physiopathology*
- From: Acta Physiologica Sinica 2023;75(2):231-240
- CountryChina
- Language:Chinese
- Abstract: Persistent neurogenesis exists in the subventricular zone (SVZ) of the ventricles and the subgranular zone (SGZ) of the dentate gyrus of the hippocampus in the adult mammalian brain. Adult endogenous neurogenesis not only plays an important role in the normal brain function, but also has important significance in the repair and treatment of brain injury or brain diseases. This article reviews the process of adult endogenous neurogenesis and its application in the repair of traumatic brain injury (TBI) or ischemic stroke, and discusses the strategies of activating adult endogenous neurogenesis to repair brain injury and its practical significance in promoting functional recovery after brain injury.
