Copper homeostasis dysregulation promoting cell damage and the association with liver diseases.
10.1097/CM9.0000000000002697
- Author:
Tao LIU
1
;
Yali LIU
;
Feiyu ZHANG
;
Yanhang GAO
Author Information
1. Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun, Jilin 130021, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Copper/metabolism*;
Homeostasis;
Oxidative Stress;
Liver Diseases
- From:
Chinese Medical Journal
2023;136(14):1653-1662
- CountryChina
- Language:English
-
Abstract:
Copper plays an important role in many metabolic activities in the human body. Copper level in the human body is in a state of dynamic equilibrium. Recent research on copper metabolism has revealed that copper dyshomeostasis can cause cell damage and induce or aggravate some diseases by affecting oxidative stress, proteasome, cuprotosis, and angiogenesis. The liver plays a central role in copper metabolism in the human body. Research conducted in recent years has unraveled the relationship between copper homeostasis and liver diseases. In this paper, we review the available evidence of the mechanism by which copper dyshomeostasis promotes cell damage and the development of liver diseases, and identify the future research priorities.
