Inhibiting ATP/P2X7R signaling protects intestinal barrier in dextran sulfate sodium-induced colitis and Crohn's disease through inactivating NF-κB pathway in macrophages.

Author: Yajun LIU ¹ ; Junbo XIAO ¹ ; Xu ZHAO ² ; Jun YI ¹ ; Yani YIN ¹ ; Xiaowei LIU ¹
Author Information

1. Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
2. Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Publication Type:Journal Article
MeSH: Humans; Animals; Mice; NF-kappa B/metabolism*; Crohn Disease/drug therapy*; Dextran Sulfate; Colitis/metabolism*; Macrophages/metabolism*; Adenosine Triphosphate/metabolism*; Mice, Inbred C57BL; Disease Models, Animal; Colon/metabolism*
From: Chinese Medical Journal 2023;136(12):1506-1508
CountryChina
Language:English