Osteoimmunology research in rheumatoid arthritis: From single-cell omics approach.
10.1097/CM9.0000000000002678
- Author:
Nan HU
1
;
Jing WANG
1
;
Bomiao JU
1
;
Yuanyuan LI
1
;
Ping FAN
1
;
Xinxin JIN
2
;
Xiaomin KANG
3
;
Shufang WU
3
Author Information
1. Department of Rheumatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
2. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China.
3. Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Osteoclasts/physiology*;
Arthritis, Rheumatoid/pathology*;
Inflammation/pathology*;
Bone and Bones/pathology*;
Bone Resorption/pathology*
- From:
Chinese Medical Journal
2023;136(14):1642-1652
- CountryChina
- Language:English
-
Abstract:
Cellular immune responses as well as generalized and periarticular bone loss are the key pathogenic features of rheumatoid arthritis (RA). Under the pathological conditions of RA, dysregulated inflammation and immune processes tightly interact with skeletal system, resulting in pathological bone damage via inhibition of bone formation or induction of bone resorption. Single-cell omics technologies are revolutionary tools in the field of modern biological research.They enable the display of the state and function of cells in various environments from a single-cell resolution, thus making it conducive to identify the dysregulated molecular mechanisms of bone destruction in RA as well as the discovery of potential therapeutic targets and biomarkers. Here, we summarize the latest findings of single-cell omics technologies in osteoimmunology research in RA. These results suggest that single-cell omics have made significant contributions to transcriptomics and dynamics of specific cells involved in bone remodeling, providing a new direction for our understanding of cellular heterogeneity in the study of osteoimmunology in RA.
