Eosinophilic gastroenteritis: Pathogenesis, diagnosis, and treatment.
10.1097/CM9.0000000000002511
- Author:
Kaiwen LI
1
;
Gechong RUAN
1
;
Shuang LIU
2
;
Tianming XU
1
;
Kai GUAN
2
;
Ji LI
1
;
Jingnan LI
1
Author Information
1. Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
2. Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Enteritis/drug therapy*;
Gastritis/drug therapy*;
Eosinophilia/therapy*;
Abdomen;
Adrenal Cortex Hormones
- From:
Chinese Medical Journal
2023;136(8):899-909
- CountryChina
- Language:English
-
Abstract:
Eosinophilic gastroenteritis (EGE) is a gastrointestinal disorder of unclear etiology that is characterized by eosinophilic infiltration of the stomach and small intestine, and consists of mucosal, muscular, and serosal subtypes. Eosinophilic infiltration of the gastrointestinal tract is a fundamental histopathological characteristic of EGE and is driven by several T-helper type 2 (Th2)-dependent cytokines and induced by food allergy. Due to the lack of a diagnostic gold standard, EGE has a high rate of delayed diagnosis or misdiagnosis. However, several new diagnostic strategies have been developed, such as novel genetic biomarkers and imaging tests. Although dietary therapy and corticosteroids remain the common choices for EGE treatment, recent decades have seen the emergence of novel treatment alternatives, such as biologics that target particular molecules involved in the pathogenic process. Preliminary investigations and clinical trials have demonstrated the efficacy of biologics and provided additional insights for the era of refractory or corticosteroid-dependent EGE biologics.
