Ferroptosis in acute leukemia.
10.1097/CM9.0000000000002642
- Author:
Tianxin LYU
1
;
Xudong LI
1
;
Yongping SONG
2
Author Information
1. Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan 450008, China.
2. Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism*;
Ferroptosis;
Cell Death;
Iron/metabolism*;
Leukemia, Myeloid, Acute
- From:
Chinese Medical Journal
2023;136(8):886-898
- CountryChina
- Language:English
-
Abstract:
Ferroptosis is an iron-dependent cell death pathway that is different from apoptosis, pyroptosis, and necrosis. The main characteristics of ferroptosis are the Fenton reaction mediated by intracellular free divalent iron ions, lipid peroxidation of cell membrane lipids, and inhibition of the anti-lipid peroxidation activity of intracellular glutathione peroxidase 4 (GPX4). Recent studies have shown that ferroptosis can be involved in the pathological processes of many disorders, such as ischemia-reperfusion injury, nervous system diseases, and blood diseases. However, the specific mechanisms by which ferroptosis participates in the occurrence and development of acute leukemia still need to be more fully and deeply studied. This article reviews the characteristics of ferroptosis and the regulatory mechanisms promoting or inhibiting ferroptosis. More importantly, it further discusses the role of ferroptosis in acute leukemia and predicts a change in treatment strategy brought about by increased knowledge of the role of ferroptosis in acute leukemia.
