Emerging role of miRNAs, lncRNAs, and circRNAs in pregnancy-associated diseases.
10.1097/CM9.0000000000002595
- Author:
Xiaoxiao FU
1
;
Yuling LI
2
;
Zhen ZHANG
1
;
Bin WANG
2
;
Ran WEI
3
;
Chu CHU
1
;
Ke XU
1
;
Lihua LI
1
;
Yonglin LIU
1
;
Xia LI
1
Author Information
1. Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.
2. Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250011, China.
3. School of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
- Publication Type:Journal Article
- MeSH:
Pregnancy;
Female;
Humans;
MicroRNAs/genetics*;
RNA, Long Noncoding/genetics*;
RNA, Circular/genetics*;
Trophoblasts;
Pregnancy Complications/genetics*
- From:
Chinese Medical Journal
2023;136(11):1300-1310
- CountryChina
- Language:English
-
Abstract:
Accumulating studies have demonstrated that non-coding RNAs (ncRNAs), functioning as important regulators of transcription and translation, are involved in the establishment and maintenance of pregnancy, especially the maternal immune adaptation process. The endometrial stromal cells (ESCs), trophoblast cells, and decidua immune cells that reside at the maternal-fetal interface are thought to play significant roles in normal pregnancy and pregnancy-associated diseases. Here, we reviewed the up-to-date evidence on how microRNA, long non-coding RNA, and circular RNA regulate ESCs, trophoblast cells, and immune cells and discussed the potential applications of these ncRNAs as diagnostic and therapeutic markers in pregnancy complications.
