Current applications for magnetic resonance-guided focused ultrasound in the treatment of Parkinson's disease.
10.1097/CM9.0000000000002319
- Author:
Haoxuan LU
1
;
Xiaoyu WANG
1
;
Xin LOU
1
Author Information
1. Department of Radiology, Chinese PLA General Hospital/Chinese PLA Medical School, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Parkinson Disease/therapy*;
Brain;
Blood-Brain Barrier;
Essential Tremor/surgery*;
Brain Neoplasms;
Magnetic Resonance Imaging/methods*;
Magnetic Resonance Spectroscopy
- From:
Chinese Medical Journal
2023;136(7):780-787
- CountryChina
- Language:English
-
Abstract:
Magnetic resonance-guided focused ultrasound (MRgFUS) is a novel and minimally invasive technology. Since the US Food and Drug Administration approved unilateral ventral intermediate nucleus-MRgFUS for medication-refractory essential tremor in 2016, studies on new indications, such as Parkinson's disease (PD), psychiatric diseases, and brain tumors, have been on the rise, and MRgFUS has become a promising method to treat such neurological diseases. Currently, as the second most common degenerative disease, PD is a research hotspot in the field of MRgFUS. The actions of MRgFUS on the brain range from thermoablation, blood-brain barrier (BBB) opening, to neuromodulation. Intensity is a key determinant of ultrasound actions. Generally, high intensity can be used to precisely thermoablate brain targets, whereas low intensity can be used as molecular therapies to modulate neuronal activity and open the BBB in conjunction with injected microbubbles. Here, we aimed to summarize advances in the application of MRgFUS for the treatment of PD, with a focus on thermal ablation, BBB opening, and neuromodulation, in the hope of informing clinicians of current applications.
