Gut microbiota: a new insight into neurological diseases.
10.1097/CM9.0000000000002212
- Author:
Lanxiang LIU
1
;
Haiyang WANG
2
;
Xueyi CHEN
2
;
Peng XIE
1
Author Information
1. Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China.
2. National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Gastrointestinal Microbiome/physiology*;
Nervous System Diseases;
Parkinson Disease;
Microbiota;
Brain
- From:
Chinese Medical Journal
2023;136(11):1261-1277
- CountryChina
- Language:English
-
Abstract:
In the last decade, it has become increasingly recognized that a balanced gut microbiota plays an important role in maintaining the health of the host. Numerous clinical and preclinical studies have shown that changes in gut microbiota composition are associated with a variety of neurological diseases, e.g., Parkinson's disease, Alzheimer's disease, and myasthenia gravis. However, the underlying molecular mechanisms are complex and remain unclear. Behavioral phenotypes can be transmitted from humans to animals through gut microbiota transplantation, indicating that the gut microbiota may be an important regulator of neurological diseases. However, further research is required to determine whether animal-based findings can be extended to humans and to elucidate the relevant potential mechanisms by which the gut microbiota regulates neurological diseases. Such investigations may aid in the development of new microbiota-based strategies for diagnosis and treatment and improve the clinical management of neurological disorders. In this review, we describe the dysbiosis of gut microbiota and the corresponding mechanisms in common neurological diseases, and discuss the potential roles that the intestinal microbiome may play in the diagnosis and treatment of neurological disorders.
