Scientific basis of acupuncture on mesenchymal stem cells for treating ischemic stroke.

Te BA; Kai-hang Sun; Jing Wang; Ze-ran Wang; Bo-mo Sang; Hong-kuan LI; Hao-ran Guo; Xue Yang; Yu-jie Zheng; Xiao-feng Zhao

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Scientific basis of acupuncture on mesenchymal stem cells for treating ischemic stroke.

Author: Te BA ^{1
,

2} ; Kai-Hang SUN ^{1
,

2} ; Jing WANG ^{1
,

2} ; Ze-Ran WANG ^{1
,

2} ; Bo-Mo SANG ^{1
,

2} ; Hong-Kuan LI ^{1
,

2} ; Hao-Ran GUO ^{1
,

2} ; Xue YANG ^{1
,

2} ; Yu-Jie ZHENG ^{1
,

2} ; Xiao-Feng ZHAO ^{1
,

2}
Author Information

1. Department of Special Needs of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of TCM, Tianjin 300193, China
2. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193.
Publication Type:Journal Article
Keywords: acupuncture; ischemic stroke; mesenchymal stem cells; stromal cell-derived factor-1α/CXC chemokine receptor 4 (SDF-1α/CXCR4) axis
MeSH: Humans; Ischemic Stroke; Chemokine CXCL12; Acupuncture Therapy; Mesenchymal Stem Cells; Inflammation
From: Chinese Acupuncture & Moxibustion 2023;43(6):691-696
CountryChina
Language:Chinese
Abstract: The scientific basis of acupuncture on mesenchymal stem cells (MSCs) for treating ischemic stroke (IS) is discussed. MSCs transplantation has great potential for the treatment of tissue damage caused by early stage inflammatory cascade reactions of IS, but its actual transformation is limited by various factors. How to improve the homing efficiency of MSCs is the primary issue to enhance its efficacy. As such, the possible mechanisms of acupuncture and MSCs transplantation in inhibiting inflammatory cascade reactions induced by IS are explored by reviewing literature, and a hypothesis that acupuncture could promote the secretion of stromal cell-derived factor-1α (SDF-1α) from ischemic foci to regulate SDF-1α/CXC chemokine receptor 4 (CXCR4) axis, thereby improving the homing efficiency of MSCs transplantation, exerting its neuroprotective function, and improving the bed transformation ability, is proposed.