Investigation of the interaction of polyamidoamine dendrimers with nicotinic acid as solubility enhancer
- Author:
Ling YE
;
Wei GU
;
Jingfa BAI
;
Jingxun ZOU
;
Hua YANG
;
Dongxu PIAO
- Publication Type:Journal Article
- Keywords:
nicotinic acid, PAMAM dendrimer, solubility enhancement
- From:
Chinese Journal of Rehabilitation Theory and Practice
2002;8(5):294-295
- CountryChina
- Language:English
-
Abstract:
ObjectivePolyamidoamine(PAMAM) dendrimers enhance the solubility of nicotinic acid. MethodsPAMAM dendrimers of generation 1 to 6 were prepared and the effect of pH and concentration of the dendrimers on the solubility enhancement of nicotinic acid was investigated. ResultsThe pH and concentration of the dendrimers influence the solubility enhancement of nicotinic acid. Conclusions Electrostatic interaction between the carboxyl group of the nicotinic acid and the amine groups of the dendrimers is involved.
