Research progress on the pharmacological effects and mechanisms of sanggenon C
- VernacularTitle:桑根酮C药理作用及其机制的研究进展
- Author:
Jianbo LIU
1
;
Xiaoling BI
2
;
Shihua WANG
2
;
Lei ZHANG
3
Author Information
1. Drug Manufacturing Room，Jingzhou Hospital of Traditional Chinese Medicine，Hubei Jingzhou 434000，China
2. Dept. of Pharmacy，Jingzhou Hospital of Traditional Chinese Medicine，Hubei Jingzhou 434000，China
3. College of Pharmacy，Hubei University of Traditional Chinese Medicine，Wuhan 430065，China
- Publication Type:Journal Article
- Keywords:
sanggenon C;
pharmacological effect;
hepatoprotective effect;
anti-tumor effect;
cardioprotective effect
- From:
China Pharmacy
2023;34(16):2034-2038
- CountryChina
- Language:Chinese
-
Abstract:
Sanggenon C is a kind of flavonoid compound mainly extracted from the traditional Chinese medicine Morus alba. The pharmacological effects and mechanisms of sanggenon C are systematically reviewed and summarized， and it is found that this component can improve pulmonary fibrosis by regulating transforming growth factor-β1 and nuclear factor-κB； it can exert anti- tumor effects by inhibiting the proliferation of tumor cells and inducing the apoptosis of tumor cells； it can exert cardioprotective， neuroprotective and hepatoprotective effects by regulating multiple signaling pathways， such as calcineurin/nuclear factor of activated T cells 2， peroxisome proliferators-activated receptor α， and Ras homolog gene family member A/Rho-associated coiled- coil containing protein kinase， enhancing autophagy， reducing inflammatory response and reducing the level of oxidative stress； it can treat osteoporosis by inhibiting osteoclast uptake and promoting osteoblast formation； it has certain inhibitory effect on many enzymes； it can exert anti-inflammatory effects by regulating nuclear factor-κB signaling pathway； it can exert antioxidant effects by scavenging free radicals. However， researches on the pharmacological effects of sanggenon C mostly focus on the cellular and animal field， and the specific mechanism of action is not yet clear. In the future， basic research and clinical trials are still needed to explore and verify.
