Research progress of stimulus-responsive transdermal drug delivery systems
- VernacularTitle:刺激响应型经皮给药系统的研究进展
- Author:
Meijing LIANG
1
;
Hongxin NING
2
;
Chuangchuang WANG
1
;
Mengyi LI
1
;
Wenbin HOU
2
;
Yiliang LI
2
;
Yang WANG
1
Author Information
1. College of Traditional Chinese Medicine，Tianjin University of Traditional Chinese Medicine，Tianjin 301617，China
2. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine，Peking Union Medical College & Institute of Radiation Medicine，Chinese Academy of Medical Sciences，Tianjin 300192，China
- Publication Type:Journal Article
- Keywords:
stimulus-response;
transdermal delivery system;
endogenous stimulation;
exogenous stimulation;
research progress
- From:
China Pharmacy
2023;34(16):2028-2033
- CountryChina
- Language:Chinese
-
Abstract:
Stimulus-responsive transdermal drug delivery systems can achieve specific drug release and improve drug utilization. According to the different stimulation modes， these preparations can be divided into endogenous stimulus-responsive， exogenous stimulus-responsive and combined stimulus-responsive transdermal drug delivery systems. The endogenous stimulation- responsive transdermal drug delivery system can respond specifically to changes in temperature and pH of the lesion site through carrier materials， so as to deliver drugs to the target site. Exogenous stimulus-responsive transdermal drug delivery system can use light， heat， magnetic， electric and other external stimulation to make the carrier material phase change， so as to achieve drug delivery. The combined stimulus-responsive transdermal drug delivery system is a combination of two or more stimulus-responsive percutaneous drug delivery systems， such as temperature-pH dual-responsive drug delivery system. At present， the relevant studies of stimulus-responsive transdermal drug delivery systems are mostly in the experimental stage， and further evaluation of stability， toxicity and skin irritation is needed in the future to lay a theoretical foundation for clinical application.
