Research progress of yeast microcapsules as oral drug delivery carrier
- VernacularTitle:酵母微囊作为口服药物递送载体的研究进展
- Author:
Yingqi LIU
1
,
2
;
Jingru LI
2
;
Fan MENG
2
;
Haonan XING
2
;
Aiping ZHENG
2
Author Information
1. College of Pharmacy，North China University of Science and Technology，Hebei Tangshan 063210，China
2. Institute of Pharmacology and Toxicology，Academy of Military Medical Sciences，Beijing 100850，China
- Publication Type:Journal Article
- Keywords:
yeast microcapsules;
β-glucan;
drug delivery carrier;
oral drug
- From:
China Pharmacy
2023;34(16):2022-2027
- CountryChina
- Language:Chinese
-
Abstract:
As a natural drug delivery carrier with rough and porous surface and hollow core， yeast microcapsules have good safety， high targeting and high stability， and have excellent application prospects in oral drug delivery systems. Yeast cells can be treated and washed with acid-base and organic solvents to obtain loose and porous yeast microcapsules. Yeast microcapsules can encapsulate drugs through electrostatic interactions， passive diffusion， hydrophobic interaction and other methods. The surface of yeast microcapsules is mainly composed of β-glucan， which can maintain stability in the gastrointestinal environment； it can be recognized by the surface-related receptors of immune cells， thus activating the immune response， and can be transported to the lesion site with the movement of lymphocytes after being ingested. Yeast microcapsules are safe and very suitable for delivering vaccines， anti-inflammatory drugs， and anti-tumor drugs. They can not only achieve oral delivery of the aforementioned drugs， but also enhance drug efficacy and improve drug targeting. In the future， more research on systemic transport mechanisms or the development of more efficient combination drug delivery systems can be carried out to fully exhibit the clinical value of yeast microcapsules.
