Calculation ability in mild cognitive impairment: A functional magnetic resonance imaging study
- VernacularTitle:轻度认知障碍患者计算能力的fMRI研究
- Author:
Jing BAI
;
Yinhua WANG
;
Xuchu WENG
;
Sheng XIE
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease (AD), mild cognitive impairment (MCI), arithmetic calculation, functional magnetic resonance imaging (fMRI)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2003;9(5):303-306
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the early diagnosis of Alzheimer's disease (AD),the arithmetic calculation ability in the patients with mild cognitive impairment (MCI) was detected under the functional magnetic resonance imaging (fMRI),combined with the neuropsychological test.Methods8 patients with MCI and 9 controls matched for the age, gender, level of education and handedness performed the subtraction of two digits presented visually while the MR machine was scanning. The raw data of the fMRI were processed with the software AFNI. The reaction time and correct ratio were analyzed with the statistical software Excel.ResultsCompared with the controls, the patients manifested longer reaction time and lower correct ratio. The patients' brain activation showed significant decrease in the inferior frontal lobe,temporal neocortex and inferior parietal area mainly in the left hemisphere. On the contrary, the activation intensity and extension in the right inferior frontal lobe were increased as compensation.ConclusionsThe patients with MCI have the deficit in calculation ability. The examination of the calculation by means of the cognitive neuropsychology and fMRI test can offer a powerful reference for the early diagnosis of AD.
