Effects of Arterial Stiffness on Visual Field Severity and Progression in Malay Patients with Primary Open Angle Glaucoma
https://doi.org/10.47836/mjmhs.18.4.5
- Author:
Kiu Kwong Yew
1
;
Sarah-Murniati Che Mat Nor
1
;
Syed Mudassar Imran Bukhari
1
;
Aida Hanum Ghulam Rasool
2
;
Liza-Sharmini Ahmad Tajudin
1
Author Information
1. Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kota Bharu, Kelantan, Malaysia
2. Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kota Bharu, Kelantan, Malaysia
- Publication Type:Journal Article
- Keywords:
Arterial stiffness, Severity, Progression, AGIS score, Primary open angle glaucoma
- From:Malaysian Journal of Medicine and Health Sciences
2022;18(No.4):27-34
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Vascular dysregulation is postulated to be involved in the pathogenesis of primary open angle glaucoma (POAG). Systemic arterial stiffness may accelerate the pre-existing damage. The purpose of this study was to determine the association of arterial stiffness with severity and progression of visual field in Malay patients with POAG.
Methods: A cross-sectional study was conducted with 55 patients with POAG and 55 age- and sex-matched control
subjects. The patients with POAG were further divided in accordance with their Advanced Glaucoma Intervention
Study (AGIS) scores on their visual fields (VFs) (mild in 23 patients, moderate in 18, and severe in 14). Progression
was defined as the worsening of the VF defect quantified as an increase in AGIS score of 4 points from the baseline.
Arterial stiffness was measured using SphygmoCor and quantified as pulse wave analysis (PWA) and pulse wave
velocity (PWV). Results: No significant differences in PWA and PWV were found between the patients with POAG
and the control subjects (p=0.333 and p=0.443, respectively). The mean follow-up duration for the patients with
POAG was 4.7±3.1 years. PWA and PWV showed no significant association with POAG severity after the confounding factors were controlled for. Ten patients with progression of VF were identified. In the analysis of covariance, a
significantly higher PWV was found in the patients with disease progression (p=0.036). Conclusion: VF severity and
progression were not associated with systemic arterial stiffness. The probable reason is that other factors affecting
retinal microcirculation may play a larger role in the severity and progression of POAG.
- Full text:11.2022my1293.pdf
