Research progress on autophagic flux regulation in cataract

VernacularTitle:自噬流调控在白内障眼病中的研究进展
Author: Cong-Yu WANG ^{1
,

2} ; Peng-Fei LI ^{1
,

2} ; Si-Wen WANG ^{1
,

2} ; Si-Jie BAO ^{1
,

2} ; Hai-Hong SHI ^{1
,

2} ; Huai-Jin GUAN ^{1
,

2}
Author Information

1. Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
2. Medical School of Nantong University, Nantong 226001, Jiangsu Province, China
Publication Type:Journal Article
Keywords: autophagic flux; cataract; lens epithelial cells
From: International Eye Science 2023;23(9):1477-1481
CountryChina
Language:Chinese
Abstract: Autophagic flux refers to a series of dynamic process of autophagic bilayer membrane formation, autophagosome formation, autophagolysosomes formation and degradation. The etiology of cataract is complex, including congenital abnormalities in lens development due to genetic mutations, oxidative damage due to aging, abnormalities in glucose metabolism due to diabetes, and proliferation of lens epithelial cells(LECs)stimulated by postoperative inflammatory factor, all of which are associated with the development of cataracts. A growing number of research in recent years have discovered that altering the status of LECs can contribute to the pathophysiological process of cataract by regulating autophagic flux. This review summarized the impacts of autophagic flux regulation on cataract.