Efficacy of traditional Chinese medicine combined with anti-vascular endothelial growth factor in the treatment of wet age-related macular degeneration: A systematic review and network Meta-analysis
10.3980/j.issn.1672-5123.2023.9.03
- VernacularTitle:中药联合抗VEGF治疗湿性年龄相关性黄斑变性的疗效:系统评价与网状Meta分析
- Author:
Nan-Nan SHI
1
,
2
;
Ming-Fang CAO
1
,
2
;
Jing LI
1
,
2
Author Information
1. Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian Province, China
2. People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine(Fujian Provincial People's Hospital), Fuzhou 350004, Fujian Province, China
- Publication Type:Journal Article
- Keywords:
wet age-related macular degeneration(wAMD);
traditional Chinese medicine(TCM);
anti- vascular endothelial growth factor;
network Meta-analysis
- From:
International Eye Science
2023;23(9):1431-1442
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To evaluate the clinical efficacy of traditional Chinese medicine(TCM)combined with intravitreal injection of anti-vascular endothelial growth factor(VEGF)or anti-VEGF medicines alone in the treatment of wet age-related macular degeneration(wAMD).METHODS:A total of eight databases were searched for relevant literatures in English and Chinese, including Chinese National Knowledge Infrastructure(CNKI), Wanfang, CQVIP, SinoMed, PubMed, Web of Science, Cochrane Library, Embase. Taking patients with wAMD as research objects, the Chinese and English clinical randomized controlled trials(RCTs)published from the databases' inception to April 20, 2022, which compared TCM combined with anti-VEGF drugs with anti-VEGF drugs alone were selected. The outcome indicators were best corrected visual acuity(BCVA)and central macular thickness(CMT). Traditional Meta and network Meta analysis were used to examine the data.RESULTS:There were 39 eligible studies among the 617 retrieved articles, involving 28 oral administration of Chinese herbal medicines and 2 757 participants. For BCVA improvement, results of TCM combination therapy were more favorable than anti-VEGF alone(MD=0.07, 95%CI: 0.05～0.09). Sheng Puhuang Decoction(SPD)ranked highest in 1 and 2mo after treatment, and Xuefu Zhuyu Capsule(XZC)ranked highest in 3mo after treatment. In terms of reducing CMT, TCM combination therapy were better(MD=-25.32 μm, 95%CI: -30.06～-20.57). Danggui Mingmu Decoction(DMD)ranked the highest in 1mo after treatment. Bushen Huoxue Decoction(BHD)ranked the highest in 2mo. Erchen Erhuang Decoction(EED)ranked the highest in 3mo.CONCLUSIONS: Compared with anti-VEGF treatment alone, TCM combination therapy led to improved BCVA and reduced CMT. However, most of the included literature is small-sample, single-center, single-blind RCTs with an overall low quality.
