Effect of SSY-B2 on improvement of learning/memory function of rats with bilateral fornix/fimbria transection
- VernacularTitle:中药SSY-B2对隔海马穹窿伞切断致大鼠学习记忆障碍的改善作用
- Author:
Huabao LU
;
Lin LI
;
Wensen AN
;
Cuifei YE
;
Li ZHANG
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine, SSY-B2, learning/memory impairment, rehabilitation
- From:
Chinese Journal of Rehabilitation Theory and Practice
2003;9(5):286-288
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect of SSY-B2 on improvement of learning/memory function of rats with bilateral fornix/fimbria transection.MethodsMale adult SD rats were divided randomly into 6 groups as sham group,model group,positive control agent piracetam group, SSY-B2 low(1.5g crude drug/kg), medium(3g crude drug/kg)and high dosage (6g crude drug/kg)group. Half to 1 hour before operation, water or drugs were fed introgastrically to each group respectively. From the fourth week, Morris water maze and tunnel water maze tests were used. Escape latency of rats in Morris test, escape latency and errors in tunnel test were recorded.ResultsIn both Morris test and tunnel water maze test, low dosage and medium of SSY-B2 markedly shorten the escape latency or reduced the errors.ConclusionsSSY-B2 can ameliorate spatial learning/memory dysfunction produced by fornix/fimbria transection. Functional compensation in other neural structure other than regeneration of the septohippocampal pathway is considered to be responsible for the effects.
