Study of ultrastructure and neuron quantitative determination in nigra-striatum of newborn rabbits with bilirubin encephalopathy
- VernacularTitle:胆红素脑病仔兔黑质-纹状体系神经元计数及超微结构的研究
- Author:
Xiaojie LI
;
Wenhua PIAO
;
Lin LI
;
Zhimei JIANG
- Publication Type:Journal Article
- Keywords:
bilirubin encephalopathy, nigra-striatum, rabbit
- From:
Chinese Journal of Rehabilitation Theory and Practice
2003;9(5):261-262
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the noxious effect and the extent of damage in nigra-striatum neuron of bilirubin.Methods30 newborn rabbits were divided into 3 groups randomly:control group(group C,12 rabbits) which were injected normal salt intraperitoneally,model group 1(group N1,12 rabbits) which were injected bilirubin 100mg/kg intraperitoneally, model group 2(group N2,12 rabbits) which were injected bilirubin 200mg/kg intraperitoneally. All the rabbits in group C and 6 rabbits in group N1(group N1a) and group 2(group N2a) were killed 6 hours after injection.Other 6 rabbits in group N1(group N1b) and group 2(group N2b) were killed 16 hours after injection. The quantity of neuron in nigra-striatum were determined,and the changes of ultrastructure were observed by electron microscope.ResultsThe neuron in nigra-striatum in group N2b were decreased compared with group C and group N1a(P<0.05),as well as with group N1b and N2a. The ultrastructure of the neuron was changed.ConclusionsThe changes in utrastructure and the quantity of nigra-striatum neuron were associated with the concentration and time of exposure under bilirubin. It is consisted with the changes of ultrastructrue and quantity in nigra-striatum.
