Clinical significance of endothelin-1 and P-selection in coronary heart disease
- VernacularTitle:内皮素与P-选择素在冠心病中的意义
- Author:
Guifang OUYANG
;
Xiaomin CHEN
- Publication Type:Journal Article
- Keywords:
acute myocardial infarction(AMI), unstable angina(UA), endothelin-1(ET-1), P-selsction, troponin I(CTnI)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2003;9(4):250-251
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explored the relationship among endothelin-1(ET-1), P-selection and troponin I(CTnI) in acute myocardial infarction (AMI) and unstable angina (UA).MethodsPlasma level of endothelin-1 was analyzed by radioimmunoassay, the expression of P-selection was analyzed by flow cytometery technique and troponin I was analyzed by paramagnetic partile chemiluminescent immunoassay in 23 AMI cases, 21 UA cases and 28 healthy controls.ResultsPlasma levels of ET-1 and CTnI in AMI patients were higher than in controls(P<0.05). The expression of P-selection in AMI patients was higher than in controls (P<0.01).Plasma levels of ET-1 and expression of P-selection in UA patients were higher than in controls (P<0.05). There was an increased trend of CTnI in UA patients in contrast to controls, but without statistical significance(P>0.05).As compared with UA, plasma levels of CTnI and expression of P-selection were elevated in AMI patients (P<0.05). No significant difference was observed between AMI and UA cases in plasma level of ET-1. Multivariate regression analysis revealed that P-selection was significantly associated with AMI and UA cases compared with plasma level of CTnI (r=0.404,P<0.01).ConclusionsPlasma levels of ET-1 and P-selection were sensitive markers as prethrombolic status.
