Preventive effct of Aprotinin and TNF-α antibody on postoperative abdominal adhesion in mice
- VernacularTitle:抑肽酶和肿瘤坏死因子-α抗体预防术后腹腔粘连实验研究
- Author:
Yanling YANG
;
Hualiang CAO
;
Xiaoping XU
;
Shuqiang YUE
- Publication Type:Journal Article
- Keywords:
peritoneal adhesion, Aprotinin, tumor necrosis factor α, mice
- From:
Chinese Journal of Rehabilitation Theory and Practice
2003;9(3):189-190
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect of aprotinin and tumor necrosis factor alpha(TNF-α) antibody on preventing postoperative abdominal adhesion in mice.Methods96 BALB/c mice were randomly divided into 4 groups:normal saline group(n=24),aprotinin group(n=24),TNF-α antibody group(n=24),and aprotinin combined with TNF-α antibody group(n=24).After an identical peritoneal injury operation,all mice were treated intraperitoneally with normal saline , aprotinin,TNF-α antibody and aprotinin combined with TNF-α respectively at the time of abdominal closure .The mice were killed 20 days after operation,the abdominal incisions and the development of intraabdominal adhesions were observed.Adhesion score was based on an overall assessment of the extent,location,and type of adhesions .ResultsAprotinin combined with TNF-α antibody group showed significantly lower adhesion score and 2-3 grade adhesion(advanced significant adhesion) rate was lower than that of other groups(P<0.01).Conclusions The intraperitoneal administration of aprotinin and TNF-α antibody can inhibit postoperative adhesion formation.
