A Case of Primary Cutaneous CD30+/ALK- Anaplastic Large Cell Lymphoma.
- Author:
Eun Ju LEE
1
;
Hyup KIM
;
Young Joon SEO
;
Ki Beom SUHR
;
Jeung Hoon LEE
;
Jang Kyu PARK
;
You Chan KIM
;
Chun Yu JIN
Author Information
1. Department of Dermatology College of Medicine, Chungnam National University, Daejeon, Korea. seokb@cnu.ac.kr
- Publication Type:Case Report
- Keywords:
CD30(Ki-1);
Anaplastic large cell lymphoma(ALCL);
Anaplastic lymphoma kinase(ALK)
- MeSH:
Aged;
B-Lymphocytes;
Cytoplasm;
Humans;
Keratins;
Leg;
Lymphocytes;
Lymphoma;
Lymphoma, Large-Cell, Anaplastic*;
Phenotype;
Prognosis;
Skin;
T-Lymphocytes;
Ulcer
- From:Korean Journal of Dermatology
2003;41(5):666-669
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary cutaneous CD30(Ki-1) positive anaplastic large cell lymphoma(ALCL) is a rare subset of cutaneous lymphoma, with a much better prognosis. ALCL is a heterogeneous process that may have a T-cell, B-cell, or indeterminant(null) phenotype and which may or may not express the anaplastic lymphoma kinase(ALK) oncoprotein. We report a case of ALCL in a 72 year old man. About 4 months ago, multiple erythematous firm ulcerative mass and satellite nodules developed on the right lower leg. The skin lesions rapidly increased in number and size. Some lesions became painful and centrally ulcered. The histologic findings showed a diffuse infiltrate of large lymphocytes with large nuclei, prominent and multiple nucleoli, and ample cytoplasm. Immunohistochemical stainings for CD30, CD5 were positive but stainings for LCA, CD3, CD45RO, CD20, cytokeratin, EMA, and ALK were negative. Therefore, we diagnosed our case as CD 30+/ALK- ALCL.
