Effect of complex prescription of Chinese medicine on ischemic brain of rat
- VernacularTitle:中药复方治疗大鼠缺血性脑损伤的药理研究
- Author:
Jian-peng XU
;
Hao DONG
;
Zhi-gang CHEN
;
Jian YANG
- Publication Type:Journal Article
- Keywords:
Chinese herbs, complex prescription, ischemic brain injury, malonaldehyde (MDA), notric oxide synthetase (NOS), superoxide dismutase (SOD), calcium, experiment
- From:
Chinese Journal of Rehabilitation Theory and Practice
2002;8(1):13-15
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the protection of Chinese herbs on the ischemic brain of rats. Methods 75 Wistar rats were divided into 5 groups, Group 1 for false operation. For the other four groups, the common carotid artery was exposed then was ligatured and cut off, Group 2 for model. From the 20th hour after operation on,Group 3, 4, 5 were fed with complex prescription of Chinese medicine named Prescription 1, 2 and 3 once a day respectively. 3 hours after taking medicine, Groups 2-5 were put in the hypoxia environment for 1 hours, then taking the medicine for 7 days. On the 7th day after operation,the blood was taken from R. atria then the rats were killed and the whole right brains were cut off. Malonaldehyde (MDA), notric oxide synthetase (NOS) and superoxide dismutase (SOD) in the brain tissue and serum, and calcium in the brain were measured respectively. ResultsThe three prescriptions can decrease the quantity of MDA both in brain tissue and serum and the calcium in brain tissue(P<0.05-0.001).Prescription 1 can enhance the activity of SOD in brain tissue while the others can decrease the activity of NOS. The hippocampus cells show tidy, and the number of the necrotic cells decrease greatly among them, Groups 4 and 5 are better than Group 3.Conclusions Prescriptions 1-3 can protect the brain tissue of the rat form ischemic brain injury.
