Experimental study of the treatment of Xingusheng(XGS) Capsule on the femoral head necrosis in mouse and rat
- VernacularTitle:新骨生胶囊治疗股骨头坏死的药理研究
- Author:
Pingping ZUO
;
Yehua WU
;
Xuekun LI
- Publication Type:Journal Article
- Keywords:
Xingusheng Capsule, Chinese herbs, necrosis of femoral head, bone density, bone repair
- From:
Chinese Journal of Rehabilitation Theory and Practice
2002;8(1):11-12
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect of XGS Capsule on the femoral head necrosis in mouse and rat. MethodsThe animal model of femoral head necrosis was caused with tretinoin per os. The free locomotive activity, bone density and pathological changed were observed. ResultsIn the model mouse, the free locomotive activity decreased significantly(P<0.01). In the model rat, the density and weight of the bone also decreased(P<0.01). The defects of cartilage, disorders of ossification and dead bone were observed in the femoral head joint. After treatment with XGS Capsule for 5 weeks, these pathological changes significantly improved. Conclusions XGS Capsule was effective in treating the femoral head necrosis.
