Study of expression of platelet-derived growth factor and its receptor in granulation tissue of burn wound and post-burn hypertrophic scar at excessive stages
- VernacularTitle:血小板源生长因子及其受体在烧伤肉芽组织和增生性瘢痕中的表达
- Author:
Xiao-song BEN
;
Tian-zeng LI
;
Shao-hai QI
;
Huizhen LIANG
;
Jianming WEN
;
Zhiming LI
;
Chaoquan LUO
- Publication Type:Journal Article
- Keywords:
burn, scar, hypertrophic scar, platelet-derived growth factor(PDGF)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2002;8(1):3-4
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the role of platelet-derived growth factor(PDGF) and its receptor in the development of hypertrophic scar. MethodsThe expression of PDGF and its receptor were detected in biopsy specimens of 9 pieces of normal skin, 7 pieces of granulation tissue of burn wound and 34 pieces of hypertrophic scar by immunohistochemical staining using specific polyclonal antibodies.ResultsPDGF and its receptor markedly increased in granulation tissue and hypertrophic scars, reaching the peak in the hypertrophic scars within 6 months and then decreased after the peak, whereas PDGF and its receptor expressed weakly in only a few normal skin specimens, and the differences were significant(P<0.05).ConclusionsThe increasing expression of PDGF and its receptor may be related to the development of hypertrophic scar.
