Study of expression of vascular endothelial growth factor in granulation tissue of burn wound and post-burn hypertrophic scar at excessive stages
- VernacularTitle:血管内皮细胞生长因子在烧伤后肉芽组织和增生性瘢痕中的表达
- Author:
Rui SHEN
;
Tianzeng LI
;
Shaohai QI
;
Yeyang LI
;
Julin XIE
;
Yingbin XU
;
Jizong ZHAO
- Publication Type:Journal Article
- Keywords:
hypertrophic scar, vascular endothelia growth factor(VEGF), tissue homogenate, expression
- From:
Chinese Journal of Rehabilitation Theory and Practice
2002;8(1):1-2
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the role of vascular endothelial growth factor(VEGF) in the growth and development of hypertrophic scar.MethodsThe burn wound samples of various stages were selected from transition of wound granulation tissue to scar and in long-persisting post-burn hypertrophic scar, and the concentrations of VEGF protein were detected using enzyme-linked immunosorbent essay (ELISA) method. ResultsThe tissue homogenate concentration of VEGF protein increases gradually from the wound granulation tissue to hypertrophic scar before it achieves summit concentration during 4 to 6 month. The concentration of VEGF degreases gradually after the maturation of hypertrophic scar. The high concentration of VEGF is synonymous with the large amount of capillary of the immature scar.ConclusionsThe abnormal expression of VEGF is related to the growth and development of hypertrophic scar and induces excessive and uncontrollable angiogenesis.
