Detection of helicobacter pylori infection by helicobacter pylori IgG serology test in pediatric patients at the Philippine General Hospital
doi.org/10.47895/amp.vi0.4843
- Author:
Eleonor G. Rodenas-Sabico
1
;
Germana Emerita V. Gregorio
1
;
Elizabeth G. Martinez
1
;
Jose Maria C. Avila
2
Author Information
1. Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, College of Medicine and Philippine General Hospital, University of the Philippines Manila
2. Department of Pathology, College of Medicine, University of the Philippines Manila
- Publication Type:Journal Article
- Keywords:
H. pylori;
Serology ELISA IgG;
Rapid Urease Test
- From:
Acta Medica Philippina
2023;57(1):28-33
- CountryPhilippines
- Language:English
-
Abstract:
Objective:To determine the validity of serum H. pylori IgG in the detection of H. pylori-associated gastroduodenitis in patients with gastrointestinal symptoms.
Methods:Cross-sectional study which included consecutive patients 1-18 years old with upper gastrointestinal symptoms who underwent esophagogastroduodenoscopy. H. pylori infection was diagnosed by positive tests for both rapid urease test (RUT) and Giemsa stain of gastric biopsies. H. pylori IgG (ELISA) serology was also performed.
Results:Twenty-five patients [Mean (SD) age: 12 (4.5) years, 68% females] were included. Majority presented with epigastric pain (64%) and had endoscopic gastritis (84%). Four patients had ulcers (1 antral, 3 duodenal). Giemsa stain was positive in 16 (64%) patients and RUT in one. Prevalence of H. pylori infection was 4%. Serum H. pylori IgG test was positive in two; borderline in three with a 100% sensitivity, 80% specificity, and a positive and negative likelihood ratio of 10.9 and 0.6.
Conclusion:The present study showed a low prevalence of H. pylori infection, thus, the validity of the H. pylori serology could not be adequately evaluated. We presently could not recommend the serum IgG in the detection of H. pylori gastroduodenitis in our setting.
- Full text:Detection of Helicobacter pylori Infection by Helicobacter pylori IgG Serology Test in Pediatric Patients at the Philippine General Hospital.pdf
