Mycophenolate Mofetil for Treatment of Autoimmune Hemolytic Anemia and Nephrotic Syndrome after Cord Blood Transplantation.
- Author:
Jae Min LEE
1
;
Sae Yoon KIM
;
Yu Kyung KIM
Author Information
1. Department of Pediatrics, College of Medicine, Yeungnam University, Daegu, Korea. mopic@yu.ac.kr
- Publication Type:Case Report
- Keywords:
Cord blood stem cell transplantation;
Graft versus host disease;
Autoimmune hemolytic anemia;
Mycophenolate mofetil;
Nephrotic syndrome
- MeSH:
Anemia, Hemolytic, Autoimmune*;
Child, Preschool;
Cord Blood Stem Cell Transplantation;
Cyclosporine;
Female;
Fetal Blood*;
Graft vs Host Disease;
Hemolysis;
Humans;
Leukemia, Megakaryoblastic, Acute;
Methylprednisolone;
Nephrosis, Lipoid;
Nephrotic Syndrome*;
Proteinuria
- From:Korean Journal of Blood Transfusion
2014;25(3):291-296
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report on a 2-year-old girl who developed autoimmune hemolytic anemia, which occurred with minimal change nephrotic syndrome 3 months after umbilical cord blood transplantation for acute megakaryocytic leukemia. Because the disease is regarded as chronic graft versus host disease and developed while taking cyclosporine medication, she was treated with methylprednisolone 2 mg/kg/day. However, hemolysis and proteinuria were refractory to steroid treatment. One week after starting methylprednisolone, mycophenolate mofetil was added. Hemolysis and proteinuria showed improvement after 2 weeks of mycophenolate mofetil medication.
