Active Components in Chinese Medicinal Herbs Regulate AMPK/mTOR Pathway to Mediate Autophagy in Diabetic Kidney Disease： A Review
10.13422/j.cnki.syfjx.20231392
- VernacularTitle:中药单体调控AMPK/mTOR通路介导自噬防治糖尿病肾脏病的研究进展
- Author:
Menghan REN
1
;
Lixia YANG
2
;
Yonglin LIANG
1
;
Ciyan LI
1
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Gansu Province Academy of Chinese Medicine， Lanzhou 730050， China
- Publication Type:Journal Article
- Keywords:
AMP-activated protein kinase （AMPK）/mammalian target of rapamycin （mTOR） signaling pathway;
active components in Chinese medicinal herbs;
autophagy;
diabetic kidney disease;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(18):277-282
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease （DKD） is one of the typical microvascular complications in patients with diabetes and a major cause of end-stage renal disease， with the pathogenesis remains to be elucidated. It may be associated with hemodynamic effects， genetic factors， kidney inflammatory injury， oxidative stress， autophagy dysregulation， metabolic disorders and so on. Because of its complex mechanism， there are no specific prevention and treatment measures in clinical practice. AMP-activated protein kinase （AMPK）/mammalian target of rapamycin （mTOR） signaling pathway is a classical pathway involved in the regulation of autophagy. This pathway can be activated for treating DKD. Recent studies have demonstrated that the active components in Chinese medicinal herbs play a role in the prevention and treatment of DKD by directly acting on targeted cells and autophagy targets， which has attracted extensive attention. Researchers have extensively studied the occurrence and development of DKD and the mechanism of drug intervention in DKD， and the results prove that AMPK/mTOR pathway plays a role in the development of this disease. The active components in Chinese medicinal herbs regulate the AMPK/mTOR signaling pathway to affect autophagy， alleviate oxidative stress， inflammation， and extracellular matrix aggregation， and promote the generation of autophagosomes， thus mitigating kidney injury. This paper mainly reviews the relationship between AMPK/mTOR signaling pathway， autophagy， and DKD and the mechanism of active components in Chinese medicinal herbs in mediating autophagy via the AMPK/mTOR pathway， aiming to provide a theoretical basis for the clinical prevention and treatment of DKD.
