Role of NLRP3 Inflammasome in Bone and Joint Diseases and Traditional Chinese Medicine Intervention： A Review
- VernacularTitle:NLRP3炎症小体在骨关节疾病中的作用及中医药干预进展
- Author:
Xiangzhou LI
1
;
Tao XING
2
;
Chaoliang QIAN
1
;
Lixia HAN
1
;
Bo YANG
1
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Gansu Provincial Hospital of Traditional Chinese Medicine， Lanzhou 730050， China
- Publication Type:Journal Article
- Keywords:
nucleotide binding oligomeric dome-like receptor protein 3 （NLRP3）;
inflammasome;
bone and joint diseases;
traditional Chinese medicine;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(18):241-250
- CountryChina
- Language:Chinese
-
Abstract:
Nucleotide binding oligomeric dome-like receptor protein 3 （NLRP3） inflammasome is an intracellular sensing protein complex， and it is an important player in the innate immune system， capable of sensing foreign pathogens and endogenous danger signals. After tissue injury， the activation of the NLRP3 inflammasome induces the release of the pro-inflammatory cytokines interleukin （IL）-1β and IL-18， while promoting gasdermin D-mediated pyroptosis. Existing studies have shown that NLRP3 inflammasome plays a key role in the occurrence and development of common bone and joint diseases such as osteoporosis， osteoarthritis， rheumatoid arthritis， and gouty arthritis by inducing inflammatory cascade reaction and accelerating bone resorption and cartilage destruction. Therefore， blocking the NLRP3 inflammasome signaling pathway may be an effective strategy to treat or prevent bone and joint diseases. Currently， researchers have developed and tested several drugs that selectively target the NLRP3 inflammasome in animal and clinical studies， but the progress has been poor due to obvious side effects and high prices. Traditional Chinese medicine （TCM） has been widely recognized in the treatment of bone and joint diseases due to its unique advantages of multi-target， multi-pathway， multi-mechanism synergism， low price， and low side effects. With the deepening of research， the targeted intervention of NLRP3 inflammasome by TCM in the treatment of bone and joint diseases has attracted wide attention. In this paper， the mechanism of NLRP3 inflammasome in osteoarthritis was summarized by analyzing relevant literature in China and abroad in recent years， and the progress of targeted intervention of NLRP3 inflammasome by TCM in the treatment of bone and joint diseases was systematically reviewed， so as to provide new ideas and theoretical basis for the treatment of bone and joint diseases.
