Chaihu Longgu Mulitang in Treatment of Coronary Heart Disease Complicated with Anxiety and Depression： A Review
10.13422/j.cnki.syfjx.20230505
- VernacularTitle:柴胡加龙骨牡蛎汤治疗冠状动脉粥样硬化性心脏病合并焦虑抑郁研究进展
- Author:
Bo NING
1
;
Xishu TAN
2
;
Hongwei HE
2
;
Hao WEN
2
;
Teng GE
1
;
Yongqing WU
1
;
Hubin YU
1
;
Lanshuan FENG
1
;
Shilin LI
1
;
Jiongdong XIE
1
;
Mingjun ZHAO
2
Author Information
1. Shaanxi University of Chinese Medicine，Xianyang 712000，China
2. Affiliated Hospital of Shaanxi University of Chinese Medicine，Xianyang 712000，China
- Publication Type:Journal Article
- Keywords:
Chaihu Longgu Mulitang;
coronary heart disease （CHD）;
anxiety and depression;
mechanism of action;
clinical research;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(18):218-228
- CountryChina
- Language:Chinese
-
Abstract:
Coronary heart disease （CHD） with atherosclerosis is a common chronic disease worldwide， and anxiety and depression are potential and crucial risk factors for adverse prognosis in CHD. Chaihu Longgu Mulitang （CLMT）， first mentioned in the Shang Han Lun （《伤寒论》）， is a classic prescription for treating Shaoyang diseases combined with disturbance of the mind and spirit， with the effects of harmonizing Shaoyang and calming the mind. Current research on mechanisms has shown that CLMT can play a role in CHD complicated with anxiety and depression through multiple pathways， including regulating related signaling pathways， inhibiting the expression of inflammatory factors， improving oxidative stress damage， modulating neurotransmitter levels， suppressing the hypothalamic-pituitary-adrenal axis， promoting mobilization of mesenchymal stem cells from the bone marrow， and inhibiting platelet activation. Clinical studies have demonstrated that CLMT significantly improves symptoms such as angina and insomnia caused by CHD complicated with anxiety and depression， effectively reduces negative emotions， improves traditional Chinese medicine （TCM） syndrome scores， and decreases levels of inflammatory factors. Furthermore， it has fewer adverse reactions and higher safety than conventional western medicine treatments. This article provides a review of the mechanisms and clinical studies of CLMT in the treatment of CHD complicated with anxiety and depression based on a comprehensive analysis of literature from the China National Knowledge Infrastructure （CNKI）， Wanfang Data， VIP， PubMed， and other databases in the past 15 years， in order to provide references for further research on the use of CLMT in the management of CHD complicated with anxiety and depression.
