Role of Ferroptosis in Cardiovascular Diseases and Chinese Medicine Treatment Based on Iron Homeostasis： A Review
10.13422/j.cnki.syfjx.20231823
- VernacularTitle:基于铁稳态代谢探讨铁死亡在心血管疾病中的作用及中医药治疗进展
- Author:
Ziyang YUAN
1
;
Yan ZHANG
2
;
Wei ZHANG
1
Author Information
1. Liaoning University of Traditional Chinese Medicine （TCM），Shenyang 110847， China
2. The Affiliated Hospital of Liaoning University of TCM， Shenyang 110000， China
- Publication Type:Review
- Keywords:
iron homeostasis;
iron metabolism;
ferroptosis;
traditional Chinese medicine;
cardiovascular disease
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(18):198-208
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases are a class of circulatory system diseases involving the heart and vessels， including arrhythmia， hypertension， coronary heart disease， myocardial infarction， heart failure and so on. Due to the complicated pathogenesis， diverse disease types， and difficult treatment， cardiovascular diseases pose serious threatens to the human health. Therefore， it is urgent to develop effective therapies. Ferroptosis， a new type of cell death different from autophagy and apoptosis， is iron-dependent and accompanied by lipid peroxide accumulation. The mechanism of ferroptosis is complex. Recent studies have shown that iron homeostasis plays a role in the occurrence of ferroptosis， which may be induced by iron intake， utilization， and output and iron-related protein synthesis. In addition， iron homeostasis and ferroptosis have been confirmed to be involved in the pathological process of cardiovascular diseases， so regulating iron homeostasis and ferroptosis in cardiomyocytes may be a focus of the future research on cardiovascular diseases. Traditional Chinese medicine （TCM） provides a unique treatment method， and the unique syndrome differentiation system and treatment methods have been widely used in the clinical diagnosis， prevention， and treatment of cardiovascular diseases. Studies have demonstrated that TCM compound prescriptions and the active components in Chinese medicinal materials can regulate iron homeostasis and ferroptosis to protect cardiomyocytes. This paper introduces the mechanism of iron homeostasis in regulating ferroptosis and summarizes the effects of iron homeostasis-mediated ferroptosis on cardiovascular diseases. Furthermore， the research progress of TCM in regulating iron homeostasis-mediated ferroptosis in cardiovascular diseases is reviewed to provide new ideas for TCM prevention and treatment of cardiovascular diseases.
