Progress on the cell therapy strategy of mesenchymal stem cells
10.12016/j.issn.2096-1456.2023.10.009
- Author:
DUAN Xingxiang
1
;
ZHANG Rui
1
;
HE Yan
2
;
PENG Youjian
3
;
YE Qingsong
4
Author Information
1. Department of Regenerative Medicine, Renmin Hospital of Wuhan University
2. Institute of Regenerative and Translational Medicine, Tianyou Hospital of Wuhan University of Science and Technology
3. Department of Stomatology, Renmin Hospital of Wuhan University
4. 1.Department of Regenerative Medicine, Renmin Hospital of Wuhan University 2.Department of Stomatology, Renmin Hospital of Wuhan University 3.Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine
- Publication Type:Review
- Keywords:
biomaterial / regenerative medicine / mesenchymal stem cells / dental pulp stem cells / cells therapies / acellular therapies / extracellular vesicle
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2023;31(10):745-750
- CountryChina
- Language:Chinese
-
Abstract:
Cell therapy based on mesenchymal stem cells (MSCs) has been a hot research topic in recent years, including the traditional cell therapy strategy based on living cells and the new cell-free therapy strategy based on soluble proteins or bioactive molecules such as extracellular vesicles (EVs). At present, MSC-induced cells have mature functions and specific structures, and insitu transplantation combined with biomaterials or organic technology has greatly improved the settlement rate and function. On the other hand, as the large-scale culture technique and EVs separation technique evolve, it is possible to obtain a large number of pure EVs, and EVs are gradually becoming a hot spot of current research. An increasing number of studies have shown that the therapeutic effect of MSCs not only occurs by implantation and differentiation but also manifests as the paracrine effect of MSCs. In this review, we discuss the emerging outcomes of cell therapies and acellular therapies to alleviate these pathological conditions.
- Full text:间充质干细胞的细胞治疗策略研究进展.pdf
