Clinical outcomes of patients treated with short-course palliative radiotherapy in the frirst year of the COVID-19 pandemic: A single institution experience
https://doi.org/10.47895/amp.vi0.4147
- Author:
Kurl E. Jamora
1
;
Nonette A. Cupino
1
Author Information
1. Division of Radiation Oncology, Department of Radiology, Philippine General Hospital, University of the Philippines Manila
- Publication Type:Journal Article
- Keywords:
Palliative radiotherapy;
Short course
- MeSH:
COVID-19
- From:
Acta Medica Philippina
2020;54(Online):1-8
- CountryPhilippines
- Language:English
-
Abstract:
Objective:This study aimed to describe the clinical profile and treatment outcomes of patients treated with a short course (<10 fractions) of palliative radiotherapy during the first year of the COVID-19 pandemic. Another aim of the study is to compare patients treated with short-course and long-course palliative radiotherapy in terms of the site and volume irradiated.
Methods:An ambispective study comprised 23 patients treated with short-course palliative radiotherapy from March 2020 to February 2021. The retrospective aspect of this study included a review of medical records and radiotherapy plans, while the prospective part involved communication with patients or legally authorized representatives via phone call. Demographic, clinical, and treatment-related information were gathered.
Results:Of 92 patients receiving palliative radiotherapy, 23 were treated with a short course, while 69 were planned for at least ten fractions. Of the 23 patients receiving short-course radiotherapy, most had colorectal (35%) and head and neck (26%) primary malignancies. The most commonly treated sites were the pelvis (24%), vertebral bones (21%), and head and neck masses (21%), and the most common indications were pain (45%) and bleeding (32%). The majority were treated with 20 Gy in 5 fractions (42%) and 25 Gy in 5 fractions (38%). Complete resolution of symptoms was observed in 43% of cases, and more than half reported no side effects (58%). Median survival was 71 days. All patients treated in the lung, stomach, and brain underwent a long course of palliative radiotherapy. Patients with a long course also had higher mean irradiated volumes (1871 cm3 vs. 2150 cm3).
Conclusion:In this single institution review, a short course of palliative radiotherapy was proven to provide good symptom control with few side effects. During the COVID-19 pandemic, its use should be strongly considered, especially in patients with poor performance status, transportation difficulties, and limited life expectancy.
- Full text:4147-Article Text-78865-1-10-20220908.pdf
